Ashley Smith

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2026-10-27 08:55:38 -

The Best Veterinary Model May Not Be the Most Advanced One
Is the most technologically sophisticated animal model always the most scientifically useful one? Not necessarily. In veterinary and comparative research, model value depends less on technological complexity than on how well the experimental system reflects the biological mechanism being investigated. Diet, metabolism, genetics, species, strain, age, and environmental exposure can all shape...

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2026-10-27 08:55:00 -

Non-Human Primate Research: Rethinking Ethics, Evidence, and Biospecimen Quality
Can a primate experiment be ethically justified when its research question could be answered using existing specimens? This question challenges researchers to consider not only what a study might discover, but whether additional animal use is necessary. Non-human primates have complex social and behavioral needs that are difficult to accommodate in laboratory environments, making careful...

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2026-10-27 08:54:27 -

The Endotoxin Testing Dilemma: Balancing Safety, Science, and Sustainability
Industry Insight | Analytical technologies, contamination control, and practical laboratory strategies The Ethical Question Behind a Critical Safety Test What happens when a laboratory method intended to protect patients depends on an animal-derived resource whose sustainability is increasingly debated? For decades, pharmaceutical manufacturers have used Limulus Amebocyte Lysate (LAL),...

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2026-10-27 08:53:45 -

Are Veterinary Biologics Being Held Back by Poor Target Selection? Rethinking Antibody Development for Companion Animals
From proteomic discovery to antigen engineering and antibody characterization, an integrated research strategy may help overcome critical bottlenecks in applied veterinary therapeutics. The Real Bottleneck in Veterinary Therapeutics May Begin Before Drug Development Veterinary medicine has a growing problem: researchers can identify promising biological targets, generate antibody candidates,...

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2026-10-27 08:53:02 -

Are Oncolytic Viruses the Future of Cancer Immunotherapy? Current Potential and Limitations
What if the next advance in cancer treatment depends not on eliminating viruses, but on engineering them to target tumor cells? The idea sounds counterintuitive. Viruses are traditionally associated with infection and disease, yet oncolytic viruses are being developed as tools that can preferentially infect and lyse susceptible cancer cells while stimulating the immune system. The bigger...

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2026-10-27 08:52:20 -

Bispecific T-Cell Engagers in Refractory Autoimmune Disease: From Oncology Strategy to Investigational Autoimmune Therapy
Conceptual visualization of a bispecific T-cell engager connecting a T cell with a target cell. Bispecific T-cell engagers have long been associated with oncology, where their ability to connect T cells with malignant cells has enabled a clinically established mechanism for targeted immune activation. Now, researchers are beginning to explore whether the same strategy could be redirected toward...

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2026-10-27 08:51:44 -

Reshaping the Immune Response Through Biomolecular Engineering: From Potent Biology to Programmable Immunity
Should scientists engineer immune responses to become more powerful—or more selective? That question is becoming increasingly important as biomolecular engineering moves beyond conventional antibody binding and toward deliberate control of immune signaling. Cytokines, antibodies, receptor ligands, and fusion proteins can be redesigned to influence which cells respond, where signaling...

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