TIGIT Immunotherapy Market Advances With Growing Focus on Immune Checkpoint Targets
Cancer immunotherapy has a new name generating buzz beyond PD-1 and PD-L1: TIGIT, short for T-cell immunoreceptor with Ig and ITIM domains. Sitting on the surface of activated T cells, natural killer cells, and regulatory T cells, TIGIT locks onto the ligands CD155 and CD112, which tumors use to keep the immune system quiet. Block that handshake, and CD226 signaling on NK and CD8+ T cells...
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