Introduction
Why do some drugs successfully treat diseases while others—seemingly perfect molecules—fail in clinical trials? The answers often lie in a microscopic world tens of thousands of times smaller than the width of a human hair, hidden deep inside our cells.
In this world, proteins play starring roles. They are the messengers that transmit signals, and the gateways that...
For decades, KRAS was considered one of oncology’s most difficult drug targets. In 2013, crystallographic studies revealed a previously unrecognized pocket beneath the switch-II region of KRAS G12C, providing a structural basis for mutant-selective inhibitor design. Years of medicinal chemistry and clinical development followed, culminating in the first FDA approval of a KRAS G12C...
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